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Guayo may refer to:

• The Great Wyomingabbreviation of the pseudonym of the Spanish comic José Miguel Monzón.
• Melicoccus bijugatus, name with which the also called is known Mammon. or quenepa.
• Guayo, name with which one is known to a town of the municipality of Comalcalco, in Tabasco, Mexico.
• Guayos, soccer shoes.
• In the Caribbean region, Rallador, food utensil.